Dispensing and dilution processes may profoundly influence estimates of biological activity of compounds.Published data show Ephrin type-B receptor 4 IC50 values obtained via tip-based serial dilution and dispensing versus acoustic dispensing with direct dilution differ by orders of magnitude with no correlation or ranking of datasets.We generated
Semantic biclustering for finding local, interpretable and predictive expression patterns
Abstract Background One of the major challenges in the analysis of gene expression data is to identify local patterns composed of genes showing coherent expression across subsets of experimental conditions.Such patterns may provide an understanding of underlying biological processes related to these conditions.This understanding can further be impr
Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts.
Takeout Containers There is a growing need to develop novel therapeutics for targeted treatment of cancer.The prerequisite to success is the knowledge about which types of molecular alterations are predominantly driving tumorigenesis.To shed light onto this subject, we have utilized the largest database of human cancer mutations-TCGA PanCanAtlas, m
Pathological internet use in adolescents
Internet addiction, which is one of the handicaps seen as a result of modern lifestyle and technological development, can be defined as the inability to prevent the desire to use the internet excessively and the need for more and Takeout Containers more time spent on the internet.Rather than banning the internet entirely, controlling its use is a m